碩士 / 中華科技大學 / 健康科技研究所 / 103 / Rutin is a polyphenolic compound with pharmacological activities including antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral antiallergic, and cytoprotective effects. In this work, sodium alginate (ALG) and carrageenan (CAR) were blended and gelled using Ca2+ to produce pH-sensitive hydrogels with various content of rutin. Their equilibrium swelling degree of the sodium alginate/carrageenan (ALG/CAR) hydrogels was evaluated at pH values ranging from 4 to 10. The results of the release experiments of rutin indicated that the release rate of rutin was higher at pH 7.4 than at pH 5.5, and decreased with the increase of the sodium alginate content in the hydrogels. The antioxidant properties of the rutin-loaded ALG/CAR hydrogels were evaluated by methods including DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging, ferrous iron chelating and total phenolic content. The results revealed that the rutin-loaded ALG/CAR hydrogels exhibited a high antiradical capacity. The MTT method indicated that the rutin-loaded ALG/CAR hydrogels exhibited good biocompatibility to L929 mouse fibroblasts. Overall results suggested that the rutin-loaded ALG/CAR hydrogels would be successfully applicable in wound dressing field.
| Identifer | oai:union.ndltd.org:TW/103CHIT0743007 |
| Date | January 2015 |
| Creators | Hsiau, Hsiu Man, 蕭秀滿 |
| Contributors | Jao, Win Chun, 饒文娟 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 58 |
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