碩士 / 嘉南藥理大學 / 化粧品應用與管理系 / 103 / Astaxanthin encapsulated with nanostructured lipid carriers (NLCs) was investigated in this study. Three different surfactants including Tween® 80 (Polysorbate 80), Poloxamer® 188 (Pluronic® F-68), Plantacare® 810 (Caprylyl / capryl glucoside) and vitamin E were used to evaluate the stability of NLCs. The purpose of the present research was to avoid oxidation and degradation of the active ingredient. The nanostructured lipid carriers were prepared by high pressure homogenizers at 500 bar 5 cycles. The stable and physical property investigation of Astaxanthin loaded nanostructured lipid carriers were stored at 4, 25 and 45℃.
The experimental results show that nanostructured lipid carriers diameter were around 200 nm with a narrow polydispersity index (PdI) lower than 0.2, the mean value of zeta potential were more than -30 mV. The encapsulation efficiency of all formulations were 100%. The stability test results showed the surfactant of Plantacare® 810 is better than Tween® 80 and Poloxamer® 188. The total NLCs recovery results of Plantacare® 810 were more than 90% after 90 days. The surfactant of Plantacare® 810 is can effectively reduce leak and degradation of active ingredient, and don’t add vitamin E to prevent oxidation of Astaxanthin.
| Identifer | oai:union.ndltd.org:TW/103CNUP0115018 |
| Date | January 2015 |
| Creators | Chu Ya-Lin, 鞠雅琳 |
| Contributors | Lin Wei-Chao, 林維炤 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 85 |
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