碩士 / 中山醫學大學 / 營養學系碩士班 / 103 / Metabolic syndrome is characterized by obesity, hypertension, hyperglycemia and dyslipidemia as well as a cluster of risk factors. Carassius auratus complex formula (CACF), including Carassius auratus, Rhizoma dioscoreae, Lycium chinense, and Rehmannia glutinosa Libosch, is a combination prescription of traditional Chinese medicine, which has been used to treat diabetes in ancient China. In vivo study, the BALB/c mice were fed with high fat diet (HFD) combined streptozotocin (STZ) supplemented with CACF to observe the effect on metabolic syndrome. In the animal model, CACF could decrease serum levels blood sugar, insulin and cytokines (TNF-α, IL-6 and leptin/adiponectin) resurved insulin resistance. Feeding CACF to mice reduced TBARS, and increased liver levels of GSH and GPx, and antioxidant enzyme. CACF could decrease lipid peroxidation in the liver and kidney, lipid accumulation in the liver and content of urine protein. In vitro study, CACF decreased apoptosis via up-regulation of p-Bad and down-regulations of phosphor-p53 and Bid on RIN-m5F cells. These results suggest that inhibit apoptosis in β cell, and decreased hyperlipid, hyperglycemia and inflammation.
| Identifer | oai:union.ndltd.org:TW/103CSMU5513021 |
| Date | January 2015 |
| Creators | Zi-Jie Chen, 陳姿潔 |
| Contributors | Jing-Hsien Chen, 陳璟賢 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 118 |
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