碩士 / 國立體育大學 / 運動科學研究所 / 103 / Purpose: Laminaria Japonica Fucoidan (FD) is a well-known bioactive constituent of seaweed extract which possess a wide spectrum of activities in biological systems including anti-cancer, anti-inflammation and modulation of immune systems. However, there are few studies for the use of FD as supplement for exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of FD on ergogenic and anti-fatigue functions following physiological challenge. Method: Male ICR strain mice were randomly assigned to three groups (n = 8 per group) for treatment: (1) Vehicle control; (2) 31 mg•ml-1 of FD (FD-1X); (3) 62 mg•ml-1 of FD (FD-2X). The three groups were orally administered for 14 days. Exercise performance and anti-fatigue function were evaluated by forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase after 15-min swimming exercise. Result: The forelimb grip strength were significantly higher by 1.17- (P = 0.007) and 1.21-fold (P = 0.001) with FD-1X and FD-2X compared with vehicle control group. The endurance swimming time was significantly increased by 1.58- (P = 0.045) and 1.23-fold (P = 0.03) with FD-1X and FD-2X compared to vehicle treatment. Serum glucose levels, values of the FD-2X groups was significantly higher by 1.16-fold (P < 0.0001) compared than the vehicle. Only FD-2X had significant decrease by 17.7% compared with vehicle control group (P =0.0544) in serum ammonia levels. Serum lactate levels were significantly lower by 18.5% (P = 0.0032) and 22.5% (P = 0.0006), respectively, with FCD-1X and FD-2X supplementations than the vehicle treatment. Therefore, FD could be a potential agent with an anti-fatigue pharmacological effect.
| Identifer | oai:union.ndltd.org:TW/103NCPE0421006 |
| Date | January 2015 |
| Creators | Yi-Hsin Tsai, 蔡宜欣 |
| Contributors | Chi-Chang Huang, 黃啟彰 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 48 |
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