碩士 / 國立臺灣海洋大學 / 生命科學暨生物科技學系 / 103 / Conversion and utilization of resources is a very economical concept of environmental protection and, while most people diatomaceous earth low value, can also be converted into high-value materials considered. In this study, the use of low-value diatomaceous earth to extract bio-silicon-silicon source, to prepare high value multifunctional bioactive glass in the holes, as a drug delivery system, to track the treatment of multi-functional applications.
Because the holes in the bioactive glass has a high specific surface area, void volume and adjustable hole size, etc., and the material is easy on the surface modification of various functional groups, it can be connected to different receptors with drugs, making it easy to enter the target Tracking cells reach therapeutic effect.
Therefore, this study takes advantage of mouse fibroblasts (L929 cell) and cervical cancer cell line (HeLa cell) for toxicity testing, and at the same time using conjugate fluorescence and confocal microscopy phagocytosis situation observed material and use with animal experiments tumors in nude mice injected subcutaneously into the material were observed with MRI development and IVIS fluorescent material position tracking material to explore whether this material has the effect of tracking treatment, and is able to inhibit tumor formation.
| Identifer | oai:union.ndltd.org:TW/103NTOU5613033 |
| Date | January 2015 |
| Creators | Yan, Zhao-Nan, 顏兆男 |
| Contributors | Lin,Hsiu-Mei, 林秀美 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 60 |
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