博士 / 國立中正大學 / 心理學系研究所 / 104 / Attention is an important cognitive function for the formation of memory. Early stage Alzheimer’s disease accompanied by reduced number of neurons in forebrain and medial- temporal lobe. These areas are related to attention and memory function. According to past studies the performance of attention control could discriminate AD and non-AD, thus performance variability in the reaction time maybe a good predictor for cognitive decline. We investigated whether intraindividual variability in an attention control task of reaction time maybe a predictor of advancing AD. We recruited 87 subjects, 28 normal aging, 33 MCI, 26 mild AD with equivalent age, sex, education. Their performance was observed twice, one year apart. Overall, the results indicate that attention control could discriminate advancing stages of AD. Intraindividual variability in reaction time is more sensitive than the mean in reaction time in predicting cognitive decline. Furthermore, attention control instability could predict normal aging converting to MCI. This finding may help early detection of AD, and develop early intervention program.
| Identifer | oai:union.ndltd.org:TW/104CCU00071015 |
| Date | January 2016 |
| Creators | CHEN, KO-CHIA, 陳可家 |
| Contributors | HSIOA, SIGMUND, WENG, CHIA-YING, 蕭世朗, 翁嘉英 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 107 |
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