碩士 / 長榮大學 / 醫學研究所 / 104 / Depression is a very common mental illness. Some research points out cause of this disease is associate with foods which are high in both fat and sugar. Recent research already proves that high fat diet would induce depressive-like behavior in mice. Hence, the purpose of our research is inducing depressive-like behavior in mice by using high fat diet, and then feeding them with antioxidant astaxanthin, and then observing if depressive-like behavior in mice can be controlled. Design of experiments is divided into control team, feeding with high fat diet plus normal saline (0.4mg/day), feeding with high fat diet plus low- dose astaxanthin (0.4mg/day), feeding with high fat diet plus mid-dose astaxanthin (0.8mg/day), feeding with high fat diet plus high-dose astaxanthin (1.6mg/day); Furthermore, observing if use of astaxanthin in behavioral experiments (tail suspension test, forced swimming test, light- dark box) could change depressive-like behavior in mice. Experimental result shows that, after 30-day experiment, feeding with high fat diet plus normal saline (0.4mg/day) would induce depressive-like behavior in mice; and, feeding with astaxanthin 0.4mg/day, 0.8mg/day, and 1.6mg/day dosage, as daily dosage increases, would also mitigate depressive-like behavior. This research proves that, feeding mice with high fat diet plus normal saline would induce depressive-like behavior, and feeding with astaxanthin would help mitigate depressive-like behavior in mice.
| Identifer | oai:union.ndltd.org:TW/104CJU05534003 |
| Date | January 2016 |
| Creators | Chung-Lin Li, 李忠霖 |
| Contributors | Tzong-Cherng Chi, 紀宗呈 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 32 |
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