碩士 / 中山醫學大學 / 營養學系碩士班 / 104 / The main cause for the subjects under renal dialysis with erythropoietin hyporesponsiveness is inflammation which is highly correlated with mortality rates of renal dialysis patients. The Eleutherococcus senticosus (ES) has anti-inflammatory activity confirmed by in vitro and in vivo experiments; however, it’s health benefits is not clear for the subjects under renal dialysis with erythropoietin hyporesponsiveness. This pilot study focused on inflammatory indicators, anemia indicators, health indicators and safety assessments on the subjects with oral administration of ES. The study is expected to recruit 30 renal dialysis patients with erythropoietin hyporesponsivenes and the subjects were randomly assigned into three groups, including mono-ES formula, combined-ES formula and placebo groups. Before and after three months of oral administration, subject’s blood specimens were taken and all indices were tested. The study has currently recruited 16 cases, but only 9 subjects completed three months of ES supplement, and their data were analyzed. Due to the small sample size, in addition to the three groups, the mono- ES and combined- ES groups were combined as experimental ES group for analysis. The Wilcoxon signed rank test compared data obtained pre- and post-treatment. The Kruskal-Wallis test was used to compare the continuous variables among the three groups, and the the Mann-Whitney U test was performed to compare the difference between the two groups. After taking ES for three months, we found that reticulocyte have significantly elevated. The safety indicators all showed no difference when comparing with placebo. The results of this study show that the supplements increase reticulocyte count for the subjects, indicating ES might have the ability to enhance patient’s erythropoiesis. Due to the current number of cases is too small, all the results should be further confirmed.
| Identifer | oai:union.ndltd.org:TW/104CSMU5513006 |
| Date | January 2016 |
| Creators | Yu-Ying Chang, 張育瑛 |
| Contributors | 楊乃成 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 49 |
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