碩士 / 義守大學 / 生物科技學系 / 104 / Steroids are some of the most frequently encountered metabolites in soft corals of the genus Nephthea. Of particular interest, steroids have been reported to diplay diverse biological activity, including antitumor, anti-inflammatory and antifouling. Our recent study on the bioactive matabolites derived from the soft coral Nephthea erecta, resulted in the isolation of a new 10-demethylated steroids, nephtheasteroid A (1), a new 19-oxygenated steroid, nephtheasteroid B (2), as well as five known metabolites, 3－6. The structure was determined by means of IR, MS, and NMR techniques. Among these metabolites, 1 is rarely found in steroids possessing a 19-norergostane skeleton. In vitro cytotoxicity study using MTT assay revealed that compounds 3－5 exhibited cytotoxicity against K－562, Molt－4, Sup－T1 and U－937, with IC50 of 3.1－10.9 μg/mL.
| Identifer | oai:union.ndltd.org:TW/104ISU05111002 |
| Date | January 2016 |
| Creators | Shih-Kai Chou, 周詩凱 |
| Contributors | Ming-Cheng Shih, 石明正 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 125 |
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