碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 104 / Skin is a mechanical and a chemical barrier against the invasion of pathogens. In addition, skin also plays an important role in the secretion, temperature homeostasis, excretion, respiration and skin sensory. Therefore, when skin damage doesn’t receive proper treatments, it will result in annoying chronic diseases. In this study, we focus on two different dermatologic disorders which are burn injury and atopic dermatitis. Both of two diseases are very common and high prevalence. Unfortunately, there are no drugs that could effectively treat burn injury and AD without side effects. Thence, developing new drugs for these diseases is imperative. The diversity of marine resources improves marine drugs to generate different bioactivities unlike terrestrial plants. For this reason, ocean may exist a promising hope to treat burn injury and AD. Marine compound (EWH) was extracted from the sea gorgonian. Our previous study also found that EWH has anti-inflammatory effects for relieving rheumatoid arthritis and reducing the pro-inflammatory cytokines. In our study, we used in vitro cell wound healing model to assess whether EWH could promote EA hy 926 endothelial cells and fibroblasts Hs68 migration. Besides, EWH could enhance angiogenesis by using zebrafish model. Next, we found that EWH could improve wound healing of burn injury by rat model and the therapeutic effect is better than silver sulfadiazine cream which is the clinical drug. On the other part, EWH may alleviate the symptoms of AD and reduce the AD score. In a word, EWH may have potential to become a promising drug to treat burn injury and AD in the future.
| Identifer | oai:union.ndltd.org:TW/104NSYS5277008 |
| Date | January 2016 |
| Creators | Meng-shan Wu, 吳孟珊 |
| Contributors | Zhi-hong, Wen, 溫志宏 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 156 |
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