碩士 / 國立中山大學 / 海洋生物科技暨資源學系研究所 / 104 / In order to search for bioactive compounds, we have studied the chemical constituents from the organic extracts of Formosan soft corals Paralemnalia digitiformis and Nephthea chabroli as well as Formosan brown alga Homoeostrichus formosana. Chromatographic frctionation of the organic solubles of Paralemnalia digitiformis has led to isolation of a new neolemnane type sesquiterpene (1) and a known compound, nardosinane type-sesquiterpenoid (2). Chromatographic purification of the organic solubles of Homoeostrichus formosana has led to the isolation of six compounds, including two new chroma(e)ne deriactives (3 and 4) along with four known compounds, fucosterol (5), cholest-5-en-3β-ol (6), phytol (7), and γ-tocophernol (8). Chromatographic separation of the organic solubles of Nephthea chabroli has led to isolation of two new dollabellane type diterpenoids (9 and 10), new prenylbicyclogermacrane diterpenoid 11 and diterpene 12 having a new skelton as well as two known compounds, pacificin A (13) and 7β-acetoxy-24-methylcholesta-5-24(28)-diene-3,19-diol (14). The structures of these compounds were established by the detailed spectroscopic analysis (IR, MS, 1D/2D NMR) and by comparison with physical and spectral data with those of literatures. The cytotoxicity of metabolites 1−14 against A-549 (human lung epithelial carcinoma) cell and HT-29 (human colon adenocarcinoma) were evaluated. Metabolite 14 exhibited significant cytotoxicity against HT-29 in vitro.
| Identifer | oai:union.ndltd.org:TW/104NSYS5277016 |
| Date | January 2016 |
| Creators | Shu-Sheng Siao, 蕭樹昇 |
| Contributors | Chang-Yih Duh, 杜昌益 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 211 |
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