碩士 / 國立清華大學 / 工程與系統科學系 / 104 / Cancer is the first leading cause of death in developed countries and the second one in developing countries, accounting for around 13% of all deaths in 2008. Conventional cancer therapy, chemotherapy, the agents are distributed non-specifically where they affect both normal and cancerous cells. Nanoparticles drug delivery carriers, by using both passive and active targeting strategies, can enhance the intracellular concentration of drugs in cancer cells while avoiding toxicity in normal cells.
In previous researches, nanoparticles drug delivery carriers focus more on directly chemo drug carrying and delivering, however, the leakage of drug during circulation and unwanted organ/tissue targeting/accumulating pose serious side effects on the therapy [3]. Therefore, instead of carrying cancer drug directly, by carrying enzyme for directed enzyme prodrug therapy (DEPT) or boric acid for BNCT in demand may solve the aforementioned issues. Because in DEPT enzymes are caged and protected inside the nanoparticles for digesting non-toxic pre-drug into cancer drug and then released into tumor cite by diffusion and in BNCT alpha particles have high linear energy transfer and short path lengths (5-9um), in terms of theory, the boron-10-loaded drugs are accumulated in tumor cells that supply a selective way to destroy malignant cells and have little effect on normal cells.
In this study, alginate-based nanoparticles was employed to carry boric acid for its good biocompatibility and diffusivity. To enhance the protection of the drug being attacked from immune system including macrophage and antibodies but not deteriorate the drug diffusion properties too much, chitosan were engineered to coating on the alginate particle surface as a tunable pore size shell. Most importantly, the fabrication processes designed in this study are both aqueous base with enzyme compatibility.
| Identifer | oai:union.ndltd.org:TW/104NTHU5593048 |
| Date | January 2016 |
| Creators | Kang, Chia Wei, 康家瑋 |
| Contributors | Tseng, Fan Gang, Yang, Chung Shi, 曾繁根, 楊重熙 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 76 |
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