碩士 / 國立臺灣科技大學 / 醫學工程研究所 / 104 / Drug delivery systems can improve drug efficacy and reduce the side effects which are widely used now. I made our drug delivery system by using drug carriers to encapsulate the drugs. Natural polymers can be used as carrier material because natural polymers have better biocompatibility and biodegradability than synthetic polymers. Alginate is a natural polymer, widely used in the food industry as an emulsifier or thickener. It can be binded with divalent cations and then formed a gel which has a network structure. Continuing the research in making alginate gel particles is necessary because there are different limitations in different preparation methods. There are few journals related to alginate gel particles which are used by two-fluid nozzle. Therefore, I chose two-fluid nozzle as an object of study. The particles were analyzed to detect particle size and appearance of patterns, assess suitable preparation parameters. It is used as a carrier to encapsulate metformin and cisplatin to evaluate encapsulate efficiency and biocompatibility.
The suitable parameters of the alginate gel particles prepared by two-fluid nozzle are: alginate concentration of at least 1.5%, spray pressure of at least 4.5 kg/cm2, calcium chloride concentration needs to be 1%, and particle size is 12-16μm. Drug encapsulation with particles experiment shows that the higher concentration of calcium chloride can increase encapsulation of drug. Results of cell experiments showed particles produced good biocompatibility, can also release the drug from the particles, so this particle for encapsulate drugs to improve drug delivery system is a feasible method.
| Identifer | oai:union.ndltd.org:TW/104NTUS5159167 |
| Date | January 2016 |
| Creators | Long-Zheng Wang, 王隆整 |
| Contributors | Chen-Yu Kao, 高震宇 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 88 |
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