碩士 / 靜宜大學 / 化粧品科學系 / 104 / Sodium alginate (SA) microcapsules were encapsulated retinol by emulsion, cross linking and drying, that Sodium alginate combined hyaluronic acid microcapsules (SAH) were prepared by the same process. In this study, the optimum conditions of SA-A microcapsules were: emulsifiers = Arlacel 2121 and Span 80, stirring speed = 7000 rpm, cross linking speed = 1000 rpm and 10 % acetic acid = 6.0 g.
The characters of microcapsules were analyzed through Optical Microscopy, Field-emission Scanning Electron Microscope (FE-SEM), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetry Analysis (TGA) and in vitro release (Transdermal Franz Diffusion Cell). SA-A microcapsules was 72.85 ± 14.01 μm, encapsulation efficiency (EE): 26.63 ± 2.67 %, loading capacity (LC): 0.44 ± 0.11 %, but SAH-A microcapsules obtained better result that was 113.29 ± 32.28 μm, EE: 55.96 ± 0.87 %, LC: 0.80 ± 0.04 %. The release amount of retinol from SA-A and SAH-A respectively which were 27.68 μg and 131.73 μg in 6 hour later. The stability study result indicated that SA-A and SAH had better stability than retinol.
10 different herbs extract as an addition agent through determination of antioxidant activity. Alcohol extract of Mucuna macrocarpa Wall. was showed that, IC50 of Scavenging DPPH free radical : 117.43 ppm; 1000 ppm extract had 596.50 mg of GAE/g; reducing power of 1000 ppm extract was equivalent to 95.11 ± 2.84 ppm BHA. In stability, microcapsules with Millettia dielsiana was provided a protective capability for retinol.
The results of SAH-A microcapsule had great protective capability, while improved release of retinol. Further, this process may possess potential application in cosmetic industry.
| Identifer | oai:union.ndltd.org:TW/104PU000115001 |
| Date | January 2015 |
| Creators | Lei, Ka Son, 李嘉順 |
| Contributors | Wu, Pey Shiuan, 吳珮瑄 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 59 |
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