Effect of cyclic stretching on the growth and morphology of fibroblasts embedded in high α-L-guluronic alginate hydrogel / 動態拉伸對包覆於高古羅醣醛酸比例海藻酸鈉水凝膠中的纖維母細胞生長與型態之影響

碩士 / 國立臺北科技大學 / 化學工程與生物科技系化學工程碩士班(碩士在職專班) / 104 / Alginate hydrogels are proving to have a wide applicability as biomaterials. We use the porosity three-dimensional structure to fills the missing part of the organization by hydrogel, to provide cell shift and nutrition transfer due to the porosity structure. It is important that scaffolds require porosity, biocompatibility and degradability. Alginate is a not only non-toxic but also water-soluble natural polymer material to fabricate scaffold. It can uniform mix with cell and to fill on the loss part of the organization, speed up the repair of the loss parts.
In the study, we used cell embedded in alginate hydrogel to test, and using rapid prototyping systems made of 3-D porous scaffold, The experimental group was cyclically stretched for 1 minute per day, the control group was static culture about cell growth, cell morphology and cell viability are compared.
The cell proliferation results show that the cells embedded in alginate fibers grew overtime. But the experimental group and control group are not difference. Because of effects of cyclic stretching on cell just 1 minute per day.

Identiferoai:union.ndltd.org:TW/104TIT05063096
CreatorsLi, Bo-Chun, 李柏俊
ContributorsLin, Hisn-Yi, 林忻怡
Source SetsNational Digital Library of Theses and Dissertations in Taiwan
Languagezh-TW
Detected LanguageEnglish
Type學位論文 ; thesis
Format0

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