碩士 / 嘉南藥理大學 / 化粧品應用與管理系 / 105 / The aim of this study was to develop and assess nanostructured lipid carriers(NLCs) compared to solid lipid nanoparticles(SLNs) encapsulated with Astaxanthin. The purpose of the present research was to avoid oxidation and degradation of the active ingredient then prolonged storage time. In this study, Encapsulation of Astaxanthin in SLN (Astaxnthin-SLN) and NLC (Astaxnthin-NLC) were prepared by hot high pressure homogenizer technique (500 bars/5cycles). The results shown that SLNs and NLCs particles were around 120 nm-170 nm diameters with narrow distribution and stable zeta potential(│25│ ~ │41│mV). The total recovery of formulations were more than 93 %, the encapsulation efficiency was 100 % for all tested formulations. The NLC prepared by Cetyl palmitate、Caprylic/Capric triglyceride and surfactant (Plantacare® 2000) was better stability and less degradation than SLN. The total recovery of Astaxanthin-NLC (PL2000) was more than 88 % after storage for 3 months, the skin irritation test results shown Astaxanthin-NLC (PL2000) was non-irritation in 72 hours. The skin efficiency test with 10 volunteers by applying the serum contains NLC (S-NLC) on their face were performed, the results shown that 70 % of people improved in moisture (P<0.05). The in vitro percutaneous absorption with Franz cell results shown that emulsion contains NLC (E-NLC) transdermal permeation of Astaxanthin was greater than Typical-emulsion (T-emulsion), they were significant increased (P < 0.05). These findings indicated that NLC could add to typical-emulsion to improve the skin penetration.
| Identifer | oai:union.ndltd.org:TW/105CNUP0115003 |
| Date | January 2017 |
| Creators | Huang,Ching-Hsiang, 黃敬翔 |
| Contributors | LIN,WEI CHAO, 林維炤 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 106 |
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