碩士 / 高雄醫學大學 / 天然藥物研究所碩士班 / 105 / Zoanthid is a radial symmetry cnidarian with two rows of tentacles and is usually found on the rocky coast of subtropical and tropical areas. The various colors of zoanthid were caused by the symbiotic relationships with single-celled algae, such as zooxanthellae, dinoflagellates and green algae. Due to its fascinating colors, this sessile benthic organism often becomes ornamentals in aquariums. In addition, zoanthids are also regarded as rich sources of novel secondary metabolites with diverse bioactivities.
In our bioactive screening of Taiwanese zoanthids, the butanol layre of P. tuberculosa was found to have potent cytotoxic and moderate anti-inflammatory activities. Therefore, a series of bioassay-guided fractionation for these animal materials was carried out. The animal material of P. tuberculosa (4.0 kg) collected from intertidal zone of the coast in Southern Taiwan was extracted by ethanol and separated by consecutive column chromatography. As a result, five new compounds, tuberazines A‒E (1‒5), and eight known alkaloids (6‒13) were isolated. The structures of all isolates were determined by analyzing their IR, Mass, NMR, and UV spectroscopic data. Moreover, cytotoxicity and anti-inflammatory activities of the isolates were evaluated.
| Identifer | oai:union.ndltd.org:TW/105KMC05068016 |
| Date | January 2017 |
| Creators | Chien-Jung Su, 蘇千容 |
| Contributors | Yuan-Bin Cheng, 鄭源斌 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 156 |
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