碩士 / 國立中興大學 / 化學工程學系所 / 105 / Collagen is one of the fibrinogen and is viewed the most abundant protein ubiquitously in living organisms. It is found in the extracellular matrix and functions to stabilize organs and connective tissues and maintains the structural integration consequently. Collagen finds its wide application in biomedicine and pharmaceutical industries. As the major supply of collagen, terrestrial animals suffers from BSE, Food and Mouth disease nowadays, and which urges the tendency of replacing terrestrial animals with aquatic ones as collagen sources. The goal of this research is to create a new type of wound dressing by mixing collagen with cellulose acetate to form a macromolecule membrane aiming at replacing the traditional wound dressing membrane. Collagen is extract collagen from fish scales and then mixed with cellulose acetate to form the membrane. Its antibacterial property is investigated. E. coli and Hay bacillus are employed to analyze growth rates on a fresh wound. Besides, water absorption and permeation of the membranes are also quantified. As a result, bacterial growth inhibition was not observed in solid medium, and wound dressing membranes made of different compositions of collagen showed no obvious difference under fluid medium. As of the quantification of permeability, the apparent permeability of vitamin C is determined as 2.3×10-5 cm/s、2.67×10-5 cm/s及1.97×10-5 cm/s for membranes made of various concentrations of collagen, elevated in 2.7 folds compared to the traditional wound dressing membrane. The membrane absorbs water with 311% of its dried weight and shows a positive result on wound recovery enhancement.
| Identifer | oai:union.ndltd.org:TW/105NCHU5063024 |
| Date | January 2017 |
| Creators | Wei-Yao Kao, 高煒堯 |
| Contributors | 張厚謙 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 62 |
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