碩士 / 國立臺灣海洋大學 / 食品科學系 / 105 / Male infertility is highly associated with metabolic disorders, like diabetes. The reproductive functions were suppressed by high oxidative stress which cause by the increased of AGEs (Advanced Glycosylation End Product). Fucoidan has been proven to have anti-tumor, improve immunity, enhance liver function, antioxidant and other effects. This study aims to investigate the effects of fucoidan on ameliorate male infertility by its antioxidative property. Male Sprague Dawley rats were induced into diabetes by high-fat diet (40%) and Streptozotocin (35 mg/kg). Fucoidan was given through oral administration in three dose (32, 128, 320 mg/kg) for 4 weeks. All rats were sacrificed in age of 14 weeks, Testis, liver, kidney and blood samples were collected for biochemical analysis. Results indicate that fucoidan can improve hyperglycemia and oxidative stress by lower fructosamine and IL-6. In tissue and sperm antioxidative assay, fucoidan shows great effects in oxidative stress and antioxidative enzyme activity tests which also led fucoidan ameliorates sperm form and motility. In testis H&E stain, the reproductive parameter have significant improve on seminiferous tubules. More recently, KISS1 have been found in peripheral tissue and testis. Leydig cell KISS1 may play a pivotal role in peripheral and neuroendocrine modulation of male reproduction. More importantly, an alter ego for KISS1 has emerged, with a significant role in regulating glucose homeostasis, insulin secretion, as well as food intake and body composition, and deficient KISS1 signaling results in reduced loco-motor activity and increased adiposity. Interestingly, hypothalamus KISS1, LH and testosterone might not been improve or even worse. These study indicated that appropriate fucoidan can ameliorate oxidative stress properties to prevent diabetes-induced male reproductive damages but not in central neuron system, like HPG-axis.
| Identifer | oai:union.ndltd.org:TW/105NTOU5253020 |
| Date | January 2017 |
| Creators | Chang, Yu-Hsuan, 張祐瑄 |
| Contributors | Kong, Zwe-Ling, 龔瑞林 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 94 |
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