碩士 / 國立臺灣大學 / 醫學工程學研究所 / 105 / Alzheimer’s disease (AD) is the most common type of neurodegenerative disease in aging society, which will reducing life quality of patients, and inconvenience to the caregivers. However, Alzheimer’s disease is currently that is no drug can successfully treat it. Current approaches focus on slowly or delay the symptoms of Alzheimer’s disease. Hence, researchers hope to develop therapies that the actual underlying cause of the disease can be prevented.
The purpose of study is to develop hydroxyapatite/donepezil which could carry drugs. The material synthesis, drug loading test, drug release test, in vitro study and in vivo study were evaluated.
In material synthesis study, donepezil is indeed into hydroxyapatite was confirmed by XRD analysis, FTIR, and SEM observations. TGA analysis showed the drug loading of hydroxyapatite/donepezil is about 12 %. The drug release tests showed hydroxyapatite/donepezil a great number of donepezil release in the acidic environment in a short time. In in vitro study, WST-1 test showed there is no negative effect on cell viability and cell proliferation. LDH test showed no cytotoxicity on cell.
The results suggest that hydroxyapatite/donepezil would be a potential candidate for prevention Alzheimer’s disease.
| Identifer | oai:union.ndltd.org:TW/105NTU05530052 |
| Date | January 2016 |
| Creators | Xue-Ying Khew, 邱雪瑩 |
| Contributors | Feng-Huei Lin, 林峯輝 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 45 |
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