碩士 / 中國文化大學 / 生物科技研究所 / 105 / Suspended particulates in the atmosphere are complex particulate matter, the main source of particulate matter are haze on the surface, dust, dust storms, burning energy, minerals, second-hand smoke and volcanic eruptions. The particle diameter less than 10μm suspended particles is called PM10, can reach through the human respiratory system and accumulate in lung. In addition, suspended particles of less than 2.5μm (PM2.5), which surface area is greater and volume is less than PM10, make it easier to adsorb toxic substance, and interfere with pulmonary gas exchange.
Our results indicated that: 1) PM2.5 exposure caused blood pressure increase, abnormal cardiac electrophysiologies (prolongation of QT interval and action potential platform stage), and structral remodeling (cardiac hypertrophy and fibrosis); 2) Fucoidan supplement can rescue these PM2.5-induced myocardial injury; 3) We also focused on the mechanism, expression of genes related to abnormal cardiac electrophysiologies and structral remodeling decreased after feeding fucoidan; 4) Organic and inorganic compounds in PM2.5 decreased after feeding fucoidan in mice blood and organs.
According to the results from my experiments, after feeding fucoidan, high blood pressure, abnormal cardiac electrophysiologies, hypertrophy, and fibrosis caused by PM2.5 in heart can be rescued. Besides, we can design some further studies based on our PM2.5-induced high blood pressure mice.
| Identifer | oai:union.ndltd.org:TW/105PCCU0111004 |
| Date | January 2017 |
| Creators | LI, KUAN-LUN, 李貫綸 |
| Contributors | LIN, YEN-CHANG, 林彥昌 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 58 |
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