碩士 / 靜宜大學 / 化粧品科學系 / 105 / Octyl methoxycinnamate (Parsol MCX) and butyl methoxydibenzoylmethane (Parsol 1789 ) are organic UV filters with less photostability. They become photo allergy or phototoxic substance with exposure to ultraviolet radiation. The organic UV filters encapsulated by microencapsulation technology. The application of UV filters in cosmetic becomes more effective and safer by microencapsulation.
In the experiment, we used sodium alginate as a shell material of the microcapsule to encapsulate octyl methoxycinnamate and butyl methoxydibenzoylmethane, calcium carbonate (CaCO3) and Tetraethyl orthosilicate (TEOS) as a crosslinking agent, and sorbitan monooleate (Span 80) and polyoxyethylenesorbitan monooleate (Tween 80) as emulsifier by interfacial polymerization method for preparation. We changed the proportion of crosslinking agents, selected the best one, and also tested the shell material concentration and crosslinking time. Then the microcapsules were characterized in terms of morphology, size, encapsulation efficiency, in vitro release studies and in vitro sun protection factor (SPF). We chose the best conditions for preparing sodium alginate composite UV filters microcapsules.
The results showed that the smallest average size were 52.10±3.11μm (MO-1-4) and 48.64± 4.74μm (MA-1-1) for Parsol MCX and Parsol 1789 microcapsules, respectively. The prepared microcapsules have different morphology, depending on the sodium alginate concentration and crosslinking time. The encapsulation efficiencies were 75.31±1.85% (MO-1-1), 62.09±2.42% (MO-1-4) for Parsol MCX microcapsules and 74.27±1.70% (MA-1-1), 74.66±2.53% (MA-1-4) for Parsol 1789 microcapsules, respectively. Sodium alginate crosslinking is better due to the high calcium content and the appropriate cross-linking time.
From the result of in vitro transdermal delivery, the UV filters containing microcapsules exhibited a significant lower release profile than that of control, Parsol MCX microcapsules decreased 90.19% (MO-1-4) and the microcapsules of Parsol 1789 microcapsules decreased 84.16 % (MA-1-4) within 6 hours and which is the lowest releasing group. After that, the release rate became steady. The results indicated that the preparation of microcapsules encapsulated Parsol MCX and Parsol 1789 may avoid photodegradation and phototoxicity phenomenon, also to decrease the direct contact of skin, reduce the chance of allergies. This effect not only enhances the protective power of the UV filters by retaining at skin surface, but also limits potential toxic reactions. On the aspect of photostabilization, for Parsol MCX, MO-1-4 sunscreen can increase 79.77% ability by compared with the control. For Parsol 1789, MA-1-4 sunscreen can increase 78.97% ability when compared with the control. Although the control sunscreen has good sun protection effect at the beginning, however, due to the instability of organic UV filters, they had greatest decay under the exposure of ultraviolet radiation. The results confirmed that microcapsules can protect Parsol MCX and Parsol 1789 through the shell material, with a low degree of decay and long-term protection.
The results in the present study indicated the microencapsulated UV filters is successful. In the future, we will develop the microcapsules which combined inorganic and organic UV filters inside, providing a wide range of UV protection.
| Identifer | oai:union.ndltd.org:TW/105PU000115002 |
| Date | January 2017 |
| Creators | Lin, Jia-Hui, 林佳慧 |
| Contributors | Wu, Pey-Shiuan, 吳珮瑄 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 95 |
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