碩士 / 國立陽明大學 / 環境與職業衛生研究所 / 105 / Introduction: Shipyard workers are exposed to various hazardous materials during their work, especially heavy metals and particulate matters (PMs) derived from welding and grinding processes. Previous studies have shown that both acute and chronic exposure to PMs were associated with increased respiratory and cardiovascular mortality. We conducted a cross-sectional study to evaluate the relation between exposure to PMs and heavy metals and selected indices of cardiovascular toxicity among the workers.
Materials and methods: 19 maintenance workers and 20 office workers in a naval shipyard in Taiwan were enrolled in this study. A SKC XR5000 air sampling pump with a MSP PM2.5 personal environmental monitor was used to collect air samples during the workers’ day shift. Desktop mobile heart rate monitor was also used to record electrocardiography and heart rate variability of all workers during their day shift. Pre- and post-shift urine samples from the same working day was collected as well. Fasting blood samples were drawan on the next morning and tested for serum biochemsitry, homocysteine, high-sensitivity C reactive protein (hs-CRP) and D-dimer. The relation between PM2.5 and heavy metals and indices of cardiovacular toxicity was then analyzed.
Results: Maintenance workers’ PM2.5 exposure was significantly higher than that of the office workers (p < 0.001). Moreover, higher PM2.5 exposure was associated with increase hs-CRP(p=0.017). Uirnary cadmium and selenium concentration were positively correlated with the vascular elasticity; Blood arsenic, lead, cadmium and selenium were positively correlated with the selected indices of cardiovacular toxicity.
Conclusions: Maintenance workers were exposed to higher PM2.5 concetration than office workers. Moreover, the concentration of some urinary and blood metals were associated with selected indices of cardiovacular toxicity, the relation of which deserves further study in the future.
| Identifer | oai:union.ndltd.org:TW/105YM005515012 |
| Date | January 2017 |
| Creators | Yu-Ci Liu, 劉育琪 |
| Contributors | Chen-Chang Yang, 楊振昌 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 168 |
Page generated in 0.1486 seconds