碩士 / 元培醫事科技大學 / 醫學影像暨放射技術系碩士班 / 105 / The no-radiation and high sensitivity magnetic resonance scanner was used to investigate the relationship between mild cognitive impairment (MCI) subjects and healthy controls by 3D chemical shift images. Twenty five volunteers (7 with MCI and 13 healthy controls) aged 50-71 years were recruited in this prospective study. 3D chemical shift images of variety of metabolites were collected from the hippocampus area of their brain. The data obtained were then analyzed by SPSS 20. In this study, we found that the metabolites level in hippocampus and corpus callosum of MCI group are generally lower than those of healthy group, especially for choline (p < 0.001) and N-acetyl aspartate (p < 0.001); but, creatine only showed significant difference (p < 0.001) in hippocampus and Myo-inositol only showed significant difference (p < 0.001) in corpus callosum. However, no significant difference was found of gender and weight between two groups. Our study demonstrated that 3D chemical shift imaging can be used to determine the difference of MCI and normal subjects. According to the literatures, the changes of metabolites are usually two months earlier than morphological changes. By use of this advantage, in clinical practice, the MCI could be diagnosed earlier and the patients could receive early treatment to improve their quality of life.
| Identifer | oai:union.ndltd.org:TW/105YUST0770010 |
| Date | January 2017 |
| Creators | KAU, YEN-LON, 高雁倫 |
| Contributors | JUANG, CHI-LONG, 莊奇容 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 65 |
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