博士 / 中國醫藥大學 / 中醫學系博士班 / 106 / Background
Dementia is a heavy burden in aging society. We analyzed the causes of dementia. Alzheimer disease (AD) is one of the most common types of dementia. Large-scale study of traditional Chinese medicine (TCM) usage among patients with AD is lacking. We look at the further detail of application.
Materials and Methods.
Used a total of 9042 adults newly diagnosed with CO poisoning were enrolled from the National Health Insurance Research Database (NHIRD) in Taiwan. The control (non- CO poisoning) cohort was 1:4 frequency-matched by age, sex, and the year of hospitalization and analyzed using a Cox proportional hazards model. Further we selected newly diagnosed patients (n = 1,939) and divided them into two categories: TCM users (n = 528; 29.11%) and non-TCM users (n = 1,286; 70.89%).
Results.
CO adjusted HR = 2.68 to Dementia. TCM users were younger than non-TCM users (75.66 vs. 79.26 years old). Among the TCM users, 60.61% were female. The median interval between diagnosis and the first TCM consultation was 7.92 months. The majority of the TCM users (63.64%) received only Chinese herbal remedies, 3.41% of TCM users were treated only with acupuncture or traumatology, and 32.95% used combined therapies. Zhi-gan-cao-tang and danshen (Radix Salviae miltiorrhizae) were the most frequently prescribed formula and single herb, respectively. Regarding the incidence rate ratio, patients with Alzheimer’s disease who had comorbid cataracts were prone to have more TCM visits, whereas those with diabetes mellitus, hypertension, stroke, or insomnia tended to have fewer TCM visits.
Conclusions.
This study revealed that CO is related Dementia, and the high prevalence and specific usage patterns of TCM in the treatment of Alzheimer’s disease. The information can utilize for further pharmacological investigation and clinical trials. We will try to use these data further analyze the extent and Traditional Chinese Medicine Application in Alzheimer patients.
| Identifer | oai:union.ndltd.org:TW/106CMCH5050007 |
| Date | January 2018 |
| Creators | Ching-Yuan Lai, 賴慶元 |
| Contributors | Jaung-Geng Lin, 林昭庚, 陳光偉 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 97 |
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