碩士 / 國立東華大學 / 海洋生物研究所 / 106 / Our group recent study of the chemical constituents of the sponge Hippospongia sp. has yielded five scalarane-type sesterterpenes (2-6). Some of these have been found to possess cytotoxic activity. In continuation of our search for bioactive metabolites from the above sponge, Hippospongia sp., we have further isolated one new sesterterpene, hippospongide D (1). Moreover, our chemical investigation on the sponge Dendoricella flabelliformis which was collected off the North Pole, has led to the isolation of one new natural product sucrose octaacetate (7).
The cytotoxic activity of 2-7 was evaluated against two cancer cell lines including HuCCT1 and SW620. The result showed that compounds 2 and 5 exhibited significant cytotoxic activity against HuCCT1 and SW620 cancer cell lines and they had significantly suppressed cell viability and increase cell apoptosis in dose-manner. Compounds 2 and 5 administration increased protein expression of apoptosis by regulates active-form of caspase-3, caspase-7 and PARP.
| Identifer | oai:union.ndltd.org:TW/106NDHU5277002 |
| Date | January 2017 |
| Creators | Shih-Han Jhang, 張仕翰 |
| Contributors | Jui-Hsin Su, 蘇瑞欣 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 61 |
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