碩士 / 國立東華大學 / 海洋生物研究所 / 106 / Studies on the chemical constiuents of the cultured soft coral Briareum violaceum had isolated twelve briarane-type diterpenoids, including seven new compounds named briaviolides K¬–Q (1–7), along with five know compounds, 2-acetoxy-2-(debutyryloxy)stecholide E (8), stecholide C acetate (9), excavatoid E (10), 2-acetoxy-2-(debutyryloxy)stecholide E acetate (11) and excavatolide Z (12). Structures of compounds 1–12 were determined by spectroscopic methods, and comparison of the spectroscopic data with other related metadolites. In addition, those compounds are tested for anti-inflammatory activity. As a result, compound 5 was found to display inhibitory effect on the accumulation of the pro-inflammatory iNOS protein in the LPS-stimulated RAW264.7 macrophage cell at a concentration of 10 M (reduced to 10.53±1.38 %).
| Identifer | oai:union.ndltd.org:TW/106NDHU5277012 |
| Date | January 2018 |
| Creators | Jing-Hao Xu, 許景皓 |
| Contributors | Ping-Jyun Sung, Jimmy Kuo, 宋秉鈞, 郭傑民 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 128 |
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