碩士 / 國防醫學院 / 公共衛生學研究所 / 106 / Aim: We assessed the relations between heavy metals, polycyclic aromatic hydrocarbons exposure and plasma nitric oxide, fractional exhaled nitric oxide, and lung function among shipyard workers.
Methods: This study was a longitudinal study. All of 354 workers were recruited from the shipyard in Taiwan from 2014 to 2016. After excluded female workers, there were 333 workers include in this study finally. Personal air sampling was collected at the first day; FeNO and lung function test were collected at the second day. In order to analyze urine heavy metals and plasma NO, we also collected blood and urine from workers in both days.
Results: In generalized estimating equation analysis, adjusting for age, waist, smoking status, time, and urinary creatinine, negative significant were found between log urinary nickel and log plasma NO (β=-0.079, 95%CI: -0.149 to -0.009, p=0.026). After adjusting for age, waist, smoking status, and time, negative significant were found between log PM2.5 and log FeNO (β=-0.051, 95%CI: -0.087 to -0.016, p=0.004). After adjusting for age, waist, smoking status, time, and urinary creatinine, negative significant were found between log urinary manganese and log FeNO (β=-0.068, 95%CI: -0.13 to -0.006, p=0.032); negative significant were found between log urinary cadmium and log plasma NO (β=-0.133, 95%CI: -0.221 to -0.045, p=0.003); negative significant were found between log urinary 1-OHP and log FeNO (β=-0.123, 95%CI: -0.233 to -0.014, p=0.028); negative significant were found between log urinary nickel and FVC% (β=-20.015, 95%CI: -34.836 to -5.194, p=0.008); FEV1 % (β=-19.159, 95%CI: -32.079 to -6.239, p=0.004); FEV1/FVC % (β=-1.983, 95%CI: -3.898 to -0.067, p=0.043).
Conclusion: In conclusion, this study showed biomarkers of exposure to Mn, Cd, Ni, and PAH are associated with decreased plasma NO, FeNO, and lung function indicators. We suggest to wearing personal protective equipment may decrease adverse health effects from occupational exposure.
| Identifer | oai:union.ndltd.org:TW/106NDMC0058049 |
| Date | January 2018 |
| Creators | HUANG,SHIH-TING, 黃詩婷 |
| Contributors | LAI,CHING-HUANG, 賴錦皇 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 167 |
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