碩士 / 國立屏東大學 / 應用化學系碩士班 / 106 / The crinoids, Colobometra perspinosa which collected from the sea area of Taiwan, had extracted with ethyl acetate, and obtained five naphthopyrone compounds, including one new compound 8-hydroxy-5,6,10-trimethoxy-2-pentyl-4H-naphtho[1,2-
b]pyran-4-one (1) and four know compounds, 5,8-dihydroxy-6,10-dimethoxy-2-methyl-4H-naphtho[1,2-b]pyran-4-one (2), 5-O-methylcomaparvin (3), comaparvin (4), 6-methoxycomaparvin-5-methyl ether (5). Compound 1 is the first maphthopyrone derivative possessing a pentyl group. The structures of compounds 1-5 were established by spectroscopic methods and by comparison of their spectroscopic data with those of related metabolites.
In the in vitro anti-inflammatory experiments (iNOS and COX-2), compound 5 were found to inhibit the accumulation of the pro-inflammatory iNOS protein (27.95%) in the LPS-stimulated RAW264.7 macrophage cells.
| Identifer | oai:union.ndltd.org:TW/106NPTU0500007 |
| Date | January 2018 |
| Creators | Hsiao, Ling-Tsung, 蕭令琮 |
| Contributors | Chung, Hsu-Ming, 鍾旭銘 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 82 |
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