碩士 / 國立臺東大學 / 生命科學系碩士班 / 106 / A cholesterol-rich diet can induce hyperlipidemia, which increases free fatty acids in the serum, causing the liver to synthesize and store excessive triglycerides. Excess fat accumulation in the liver can lead to steatosis and nonalcoholic fatty liver disease. Pure and low-temperature deep ocean water (DOW) is known to be rich in minerals and nutrients, which according to numerous studies have multiple health benefits. These include lowering blood lipid level and blood pressure, suppressing metastatic breast cancer, and increasing resistance to fatigue, as well as improving obesity, diabetes, cardiovascular diseases, and skin conditions. Furthermore, the literature indicates that the magnesium ions in DOW can effectively alleviate cardiovascular diseases, but how DOW of varying mineral compositions differs in the control of blood lipid levels remains unclear. The present study compared how the DOW, DOW with low sodium and potassium, DOW with low calcium, differed in their effects on blood lipid level. An in vivo test was conducted in which hamsters were fed with a cholesterol-rich diet, and after they developed hyperlipidemia, they were fed with DOW, DOW with low sodium and potassium, DOW with low calcium for 8 consecutive weeks to observe how their blood lipid levels varied. The results indicated that DOW can significantly lower high total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels induced by a cholesterol-rich diet; furthermore, DOW can also lower aspartate transaminase (AST) levels, which is an indicator of liver inflammation. Overall, magnesium, calcium DOW was determined to be the most effective at lowering TC and triglyceride levels, and it was also significantly effective (p > .05) at reducing hepatic lipid peroxidation and removing artery plaque. Regarding antioxidant enzyme activity, the three types of DOW were discovered to be effective at raising the activity of superoxide dismutase and catalase in hamster livers. In summary, magnesium, calcium DOW was the most effective at regulating blood lipid level because it surpassed the other two in lowering the TC level, artery plaque removal, and raising antioxidant enzyme activity. This suggests that the interaction between Mg2+ and Ca2+ may be key to the effectiveness of DOW in regulating blood lipids and antioxidizing the liver.
| Identifer | oai:union.ndltd.org:TW/106NTTU5105007 |
| Date | January 2018 |
| Creators | Kao-ko Lin, 林高可 |
| Contributors | Chun-Lin Lee, 李俊霖 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 65 |
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