碩士 / 國立臺灣科技大學 / 化學工程系 / 106 / Cyanophycin granule polypeptide consist of lysine and arginine as the side chains, and is biodegradable, temperature responsive and low toxicity. Thus it has a potential in biomedical applications, such as drug delivery. However, the water insoluble cyanophycin cannot be dissolved in neutral aqueous solution which to become a limitation to its current developments.
This study focused on using sugar acid and sugar amine to modify insoluble cyanophycin, and also on using glucose to crosslink the insoluble cyanophycin with PEI. In order to investigate the physical properties of the grafted polymer physical properties, we used different purification methods, solvents, pHs and concentrations. The grafted polymers with positive and negative charges were mixed at different ratios to examine the changes in the surface charges.
The results showed the grafting of sugar acid and sugar amine could enhance the solubility of insoluble cyanophycin, and the phase transition temperatures to around 37℃. The functional groups and carbon chain lengths affected the phase transition temperatures and the particle sizes. Different solvents and purification methods could result in differences in the particle sizes for the same grafting. The grafting with positive and negative charges still retained the characteristic of the temperature responsive property.
| Identifer | oai:union.ndltd.org:TW/106NTUS5342057 |
| Date | January 2018 |
| Creators | Wen-Ling Lai, 賴玟伶 |
| Contributors | Wen-Chi Tseng, 曾文祺 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 133 |
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