碩士 / 臺北醫學大學 / 保健營養學研究所 / 106 / Non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of arthritis and cardiovascular disease are commonly associated with the occurrence of gastric ulcer. The objectives of this study were to investigate the effects of Lycium barbarum polysaccharides (LBP) and C-phycocyanin (CPC) on healing of aspirin-induced gastric ulcer in rats. Male Sprague-Dawley rats were divided into 5 groups: normal, aspirin, aspirin + LBP (100 mg/kg bw/d), aspirin+ CPC (50 mg/kg bw/d), and aspirin + LBP (50 mg/kg bw/d) + CPC (25 mg/kg bw/d). The treatments were given from the first week to the nineth week, and aspirin (700 mg /kg bw/d) was used to induce gastric ulcer in the second week to the nineth week. The treatment of LBP reduced ulcer score and CPC reduced MDA levels. The MIX group suppressed MDA levels, increased COX-1, NO, and PGE2 levels. Both treatments increased Bifidobacterium in the stomach. Therefore, after aspirin -induced gastric ulcer for 8 weeks in rats, LBP reduces ulcer index, and CPC inhibits oxidation in rats with aspirin-induced gastric ulcer. LBP combined with CPC improves gastroprotective factors and antioxidation. In addition, LBP or CPC could improve gastric microbiota. Both LBP and CPC have effects on healing of aspirin-induced gastric ulcer.
| Identifer | oai:union.ndltd.org:TW/106TMC05217017 |
| Date | January 2018 |
| Creators | Shu-Yu Hsieh, 謝書毓 |
| Contributors | Jane C-J Chao, 趙振瑞 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 90 |
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