碩士 / 中華科技大學 / 健康科技研究所 / 107 / Ferulic acid, a type of phenolic acid, has been shown to possess variors pharmacological effects such as antioxidant, anti-inflammatory, antibacterial, antithrombotic and anticancer effects. In this study, the homogeneous solution of sodium alginate and konjac was dropped into calcium chloride solution and crosslinked by Ca2+ ions to form pH-sensitive hydrogel beads. The swelling behaviors of the sodium alginate/konjac hydrogel beads as a function of pH values were investigated. The sustained release profiles of ferulic acid loaded hydrogel beads were studied in simulated intestinal fluid (SIF) and simulated colonic fluid (SCF). Total phenolic content was estimated by Folin-Ciocalteau method. Antioxidant activity was determined by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity and ferrous ion chelating ability assays. The cytocompatibility of the sodium alginate/konjac/ferulic acid hydrogel beads was evaluated in vitro based on the proliferation of L929 mouse fibroblast. In summary, the sodium alginate/konjac hydrogel beads have the potential of being applied to oral delivery of site-specific drugs.
| Identifer | oai:union.ndltd.org:TW/107CHIT0743001 |
| Date | January 2019 |
| Creators | YEH, SAN-HUA, 葉珊華 |
| Contributors | JAO, WIN-CHUN, 饒文娟 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 55 |
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