碩士 / 中華科技大學 / 健康科技研究所在職專班 / 107 / Ferulic acid, a major active constituent of Chinese medicinal herbs, exhibits a variety of biological activities such as antioxidant, anti-inflammatory, anti-allergic, anti-cancer, and antibacterial effects. Erythromycin, a macrolide antibiotic, is commonly used in treatment of many bacterial actions. Ferulic acid-loaded and erythromycin-loaded hydrogel beads as oral delivery formulations were studied. In this work, the homogeneous sodium alginate/guar gum solution was dropped into calcium chloride solution, crosslinked by calcium ions, and the pH-sensitive hydrogel beads were formed. The swelling behaviors of sodium alginate/guar gum hydrogel beads were studied at different pH environment. The sustained release profiles of ferulic acid-loaded hydrogel beads were investigated in simulated intestinal fluid (SIF) and simulated colonic fluid (SCF). The total phenolic content and antioxidant activity of Ferulic acid-loaded hydrogel beads were evaluated using the Folin-Ciocalteau method, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity and ferrous ion chelating ability assays. The MTT assays show that the sodium alginate/guar gum/ferulic acid hydrogel beads have good biocompatibility, which allow adhesion and proliferation of the L929 fibroblast cells. Finally, the antibacterial actions against gram-negative (E. coli) and gram-positive (S. aureus) bacteria of sodium alginate/guar gum/erythromycin hydrogel beads have been investigated. These results indicated that ferulic acid-loaded and erythromycin-loaded sodium alginate/guar gum hydrogel beads show a promising application in drug carriers.
| Identifer | oai:union.ndltd.org:TW/107CHIT1743007 |
| Date | January 2019 |
| Creators | YU, YUEH-CHIN, 俞月琴 |
| Contributors | JAO, WIN-CHUN, 饒文娟 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 57 |
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