碩士 / 明志科技大學 / 材料工程系碩士班 / 107 / For the hemodialysis treatment, protein-bound uremic toxins are difficult to eliminate via dialysis. Therefore, these toxins accumulate would become players in the multitude of pathologies observed in kidney disease patients. In this present work, we developed a kind of efficient, safe and biocompatible of hemoperfusion devices for protein-bound uremic toxin removal from the artificialbiofluids. The adsorbentin hemoperfusion devices is prepared through the multiwall carbon nanotubes (MWCNTs)- poly(,-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) nanohybrid technologies and the corresponding freeze-drying process for producing conducting polymer nanocomposite sponges. First, different additives and the controlled freeze-drying process were used to study the dispersion, pore size distribution,morphological and electrical properties, and wet stability of MWCNT-PEDOT nanocomposite sponges for meeting the regulatory requirements of protein-bound uremic toxin (p-cresol) purification. Second, we further integrate these MWCNT-PEDOT nanocomposite sponges into bioelectronic sensors for real-time detection of p-cresol during four hours of hemoperfusion. Therefore, an effective strategy to develop a novel organic bioelectronic device was provided, showing great potential applications for hemoperfusion treatment, as well as for monitoring the adsorption amount of protein-bound uremic toxinsviaperfusion process.
| Identifer | oai:union.ndltd.org:TW/107MIT00159002 |
| Date | January 2018 |
| Creators | CHEN,PO-YU, 陳柏宇 |
| Contributors | HSIAO,YU-SHENG, 蕭育生 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 61 |
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