碩士 / 明志科技大學 / 材料工程系碩士班 / 107 / For hemodialysis treatment, protein-bound uremic toxins (PBUTs) are difficult to eliminate by dialysis. Therefore, these toxin accumulations will become participants in numerous pathological changes observed in patients with kidney disease. In this work, we have developed an efficient and safe and biocompatible hemoperfusion (HP) device for the removal of protein-bound uremic toxins from artificial biological fluids. Adsorbent Blood Perfusion Device Through Quantitative GOPS (3-Glycidyloxypropyl) (trimethoxysilane) and Different Doping Agents [Multiwalled Carbon Nanotubes (MWCNTs); Zeolite; Graphene Oxide (GO)]-Poly (3,4) - Ethylenedioxythiophene : poly (styrene sulfonic acid) (PEDOT: PSS) nanocomposite technology applied freeze drying process to produce conductive polymer nano composite sponge. In this study, we first evaluated the static behavior of urea toxins with different adsorbents [zeolite; carbon nanotubes; graphene oxide] against urine toxin (P-cresol, Indoxyl sulfate, hippuric acid, creatinine) and observed adsorption. effectiveness. For material analysis, we performed morphological analysis of the material by scanning electron microscopy and electroanalyzed the material using a four-point probe and potentiostat. Finally, we performed a perfusion experiment for more than four hours to evaluate the dynamic adsorption efficiency of four urea toxins with polymer conductive polymer nanocomposite sponges.
| Identifer | oai:union.ndltd.org:TW/107MIT00159022 |
| Date | January 2019 |
| Creators | CHUNG,CHUAN-KAI, 鍾傳鎧 |
| Contributors | HSIAO,YU-SHENG, 蕭育生 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 105 |
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