碩士 / 中國文化大學 / 化學系應用化學碩士班 / 107 / The aim of this study is to prepare an oxygen-generated nanocomposite (CaO2/ICG/alginate/Au nanorod) and then apply for photothermal (based on Au NRs) and photodynamic therapies (based on ICG). First, Au nanorods (NRs) with as aspect ratio of 3.8 were synthesized and then alginate was used to cover the surface of Au NRs with electrostatic interaction. Indocyanine green(ICG) was selected as a photosensitizer for photodynamic therapy in this study.Alginate-conjugated Au NRs could encapsulate ICG and then Ca2+ was used to cover the surface of alginate-conjugated Au NRs (alginate-Au NRs) to prevent ICG leaching from material surface. Final, Ca2+-alginate-Au NRs could be transfer to CaO2-alginate-Au NRs after Ca2+ reacts with H2O2. CaO2 can react with water to produce O2. When Ca2+-alginate-Au NRs exist in tumor region, O2 can be generated and then the hypoxia microenvironment will be improved (O2level increase), resulting in better therapeutic efficiency. CaO2/ICG/alginate/Au NRs combined photothermal therapy, photodynamic therapy and O2 generation to treat tumor. This is a new strategy for tumor treatment with high therapeutic efficiency, as compared to current tumor treatment methods.
| Identifer | oai:union.ndltd.org:TW/107PCCU0500004 |
| Date | January 2019 |
| Creators | LYU, LING, 呂翎 |
| Contributors | CHENG, FONG-YU, 鄭豐裕 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 54 |
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