碩士 / 大仁科技大學 / 藥學系碩士班 / 107 / Morinda citrifolia Linn known as “Noni”, is an evergreen shrub native from Southeastern Asia to Australia, and is used to be a traditional medicine. The ripe fruit of noni has a strong cheese-like smell and flavor. The recent studies have shown that the noni fruit has various pharmacological effects, such as anti-oxidation, anti-inflammatory activities and immumoregulation. The objective of this study was to investigate the immunomodulation of noni juice (NJ) and their fermentation juice (fNJ) products using an in vivo murine model. Two fermentation juice products made from noni fruits that fermented for two or six months, respectively. The products were coded as 2-fNJ and 6-fNJ. A murine model was established to investigate the health functions of the noni fruit products, including the lipid metabolism, antibody secretions, pro-/anti-inflammation and inclination of Th1(T-helper cell type1 )/Th2 balance. Experimental mice were divided into four groups, including one control group and three supplement groups (150 mg/kgBW/day): NJ, 2-fNJ and 6-fNJ. All experimental mice were sacrificed at day 35. The results showed that 2-fNJ supplement significantly (p < 0.05) increased the serum HDL-/LDL- cholesterol ratio, and 6-fNJ supplement significantly (p < 0.05) increased the Th1-/Th2-type cytokine secretion ratios in the Con A-stimulated splenocyte cultures. It was suggested 6-fNJ could modulate the Th1/Th2 balance toward Th1 pole in the murine model.
| Identifer | oai:union.ndltd.org:TW/107TAJ00551015 |
| Date | January 2019 |
| Creators | LIN,CHING-CHI, 林青吉 |
| Contributors | LIN, FENG-LANG, CHANG, HUI-HSIANG, 林鳳蘭, 張惠香 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 60 |
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