碩士 / 國立臺北科技大學 / 化學工程與生物科技系化學工程碩士班 / 107 / Chitosan and alginate particles were prepared by a continuous-feed ultrasonic atomizer coupled with a heating column. The formation of the microparticles was investigated at various compositions of the chitosan, alginate, and crosslinker, and different drying conditions. The size and morphology of the dried particles were observed by a scanning electron microscope (SEM). The particle size could be reduced by decreasing the concentration of the biopolymers in the solution. The analysis revealed that the most types of chitosan or alginate particles prepared were of spherical shape, and the production yield could be higher than 85%. It was found that the particles with different sizes, from approximately 270nm and 630nm, can be prepared successfully at various concentrations. The geometric standard deviations (GSDs) of the dried particle size were almost less than 2, which showed a narrow size distribution. The stability of chitosan or alginate particles in aqueous solution was further observed by a dynamic light scattering (DLS) and a zeta potential analyzers. It was found that the particle size and zeta potential were dependent on the ratio of the crosslinker in the feed and the pH value of solution.
| Identifer | oai:union.ndltd.org:TW/107TIT0006A042 |
| Date | January 2019 |
| Creators | LI, CHIH-YING, 李芝穎 |
| Contributors | CHENG, KUO-CHUNG, 鄭國忠 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 114 |
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