Experiments were carried out to investigate the extent to which habituation
of the flexor reflex depended on mechanisms operating at spinal interneurones. An attempt was made to cause selective degeneration of interneurones in the spinal cord of the rat by subjecting the cord to a period of ischaemia. Ischaemia was produced by temporary occlusion of the thoracic aorta. The flexor withdrawal reflex was tested 3, 7 or 14 days after occlusion. When compared with data from control animals it was found that ischaemia had resulted in both a qualitative change and a quantitative
diminution in the amount of habituation which occurred during the presentation of 400 uniform stimuli. It was concluded that this impairment
of the habituation process was a consequence of degeneration of interneurones which normally cause progressive inhibition of the excitatory flexor reflex pathway. / Medicine, Faculty of / Cellular and Physiological Sciences, Department of / Graduate
| Identifer | oai:union.ndltd.org:UBC/oai:circle.library.ubc.ca:2429/33288 |
| Date | January 1972 |
| Creators | Krajina, Vladimir Peter Jan |
| Publisher | University of British Columbia |
| Source Sets | University of British Columbia |
| Language | English |
| Detected Language | English |
| Type | Text, Thesis/Dissertation |
| Rights | For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use. |
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