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Percutaneous penetration and anti-inflammatory activity of desfluorotriamcinolone acetonide

Desonide, a new topical anti-inflammatory and antipruritic
steroid, has been investigated for its clinical, vasoconstrictor and in vitro percutaneous penetration properties,
and compared to betamethasone 17-valerate, triamcinolone
acetonide and hydrocortisone. The clinical and vasoconstrictor bioassay tests place desonide quantitatively among the most effective topical anti-inflammatory agents, possibly because of its relatively rapid skin penetration rate.
The significance of the study is (a) it provides
definitive data on topical anti-inflammatory effectiveness of desonide and (b) it reveals that, contrary to current
opinion, fluorination of the steroid molecule may be unnecessary for topical anti-inflammatory activity, and that 9 °C-fluorination in prednisolone acetonides impedes rather than favours their skin penetration rates.
New data on octanol/water partition coefficients and an unsuccessful effort of adopting the Martin (1968) oxime derivative spectrophotofluorometric technique for desonide assays are also included. / Pharmaceutical Sciences, Faculty of / Graduate
Date January 1972
CreatorsVerma, Subhash Chander
PublisherUniversity of British Columbia
Source SetsUniversity of British Columbia
Detected LanguageEnglish
TypeText, Thesis/Dissertation
RightsFor non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use

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