Desonide, a new topical anti-inflammatory and antipruritic
steroid, has been investigated for its clinical, vasoconstrictor and in vitro percutaneous penetration properties,
and compared to betamethasone 17-valerate, triamcinolone
acetonide and hydrocortisone. The clinical and vasoconstrictor bioassay tests place desonide quantitatively among the most effective topical anti-inflammatory agents, possibly because of its relatively rapid skin penetration rate.
The significance of the study is (a) it provides
definitive data on topical anti-inflammatory effectiveness of desonide and (b) it reveals that, contrary to current
opinion, fluorination of the steroid molecule may be unnecessary for topical anti-inflammatory activity, and that 9 °C-fluorination in prednisolone acetonides impedes rather than favours their skin penetration rates.
New data on octanol/water partition coefficients and an unsuccessful effort of adopting the Martin (1968) oxime derivative spectrophotofluorometric technique for desonide assays are also included. / Pharmaceutical Sciences, Faculty of / Graduate
| Identifer | oai:union.ndltd.org:UBC/oai:circle.library.ubc.ca:2429/33373 |
| Date | January 1972 |
| Creators | Verma, Subhash Chander |
| Publisher | University of British Columbia |
| Source Sets | University of British Columbia |
| Language | English |
| Detected Language | English |
| Type | Text, Thesis/Dissertation |
| Rights | For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use. |
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