<p> </p><p>In previous studies the carboxyl-terminus of microtubule-associated protein 1S was shown to interact with the <em>N</em>-methyl-D-aspartate receptor subunit NR3A (Eriksson <em>et. al.</em>)<sup>1</sup>. In this study, interactions between three truncations of the microtubule-associated proteins 1B and one truncation of the microtubule-associated protein 1S carboxyl-terminus and the <em>N</em>-methyl-D-aspartate receptor subunits NR1 and NR3A were examined. The study showed that an interaction occurred between amino acids 2167 to 2365 of the microtubule-associated protein 1B and NR3A. That region of microtubule associated protein 1B corresponds to a microtubule-binding region in the light chain. It has been shown in earlier studies (Reviewed in Halpain S. <em>et a1<sup>2</sup></em>, Riederer, BM<em>. et.al<sup>3</sup></em>.) that the light chain is a active part of the protein that have been post translational cleaved. The MAP 1 proteins are present in all tissue but has higher concentrations in the Post Synaptic Density of neurons in the central nervous system. The <em>N</em>-methyl-D-aspartate receptors are present in glial cells and in the dendritic shafts of the central nervous system neurons (Eriksson <em>et. al.</em>)<sup>1 </sup>. The diseases were these proteins may play a part is mainly memory destructive diseases such as Alzheimers disease and in muscular dystrophy, but these assumptions are still being speculated.</p><p> </p>
| Identifer | oai:union.ndltd.org:UPSALLA/oai:DiVA.org:mdh-1196 |
| Date | January 2008 |
| Creators | Björklund, Stefan |
| Publisher | Mälardalen University, School of Sustainable Development of Society and Technology |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, text |
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