Exosomes are nanosized vesicles that contain proteins and nucleic acids. They are released and taken up by many different cell types as a way of cell-to-cell communication. It has previously been recognized that exosomes released by cancer cells promote tumor progression. Moreover, recent studies have increasingly found evidence that microRNA contained within cancer derived exosomes plays an important role in tumor progression. In this manuscript, the current knowledge on exosomes, the sorting of microRNA into exosomes as cargo, the gene regulatory mechanisms of microRNA, and recent findings on the tumor promoting actions of exosomal microRNAs on gastric cancer, hepatocellular carcinoma and breast cancer, is reviewed. The information gathered emphasizes the importance of exosomal microRNAs that increase tumor growth in the development of cancer treatment and research.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:liu-167056 |
| Date | January 2020 |
| Creators | Johansson, Emil |
| Publisher | Linköpings universitet, Institutionen för fysik, kemi och biologi |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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