Thesis under the direction of Dr. Jeremy L. Warner
The practice of oncology increasingly relies on genetic information from tumors to determine diagnosis, prognosis and therapy. These tumor molecular profiling reports are generated by clinical laboratories specializing in molecular diagnostics; however, there is no consensus on what the reports should contain, how they should be structured, or how best to transmit and present them to oncologists. This thesis outlines a framework for the data elements, file structure, transmission requirements, clinical information technology requirements and secondary use cases for molecular profiling. This framework is used as a guide to describe the implementation of tumor molecular profile reports into clinical workflows. The experience of implementing automated structured molecular profile reports from a third party laboratory into an electronic health record is described. Using file structures and data elements from the framework, molecular profile genetic data and sample metadata can be accurately parsed, restructured and aggregated for secondary uses. A system of parsing this data into a database and the use cases this database satisfies is described. This framework helps to inform clinical and translational uses of tumor molecular profiling.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-03252016-111331 |
| Date | 11 April 2016 |
| Creators | Rioth, Matthew John |
| Contributors | Jeremy L Warner, Paul Harris, Mia Levy, Carlos Arteaga |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-03252016-111331/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
Page generated in 0.0061 seconds