Cyclooxygenase-2 (COX-2) has long been known to be a facilitator of colorectal neoplasia, specifically in the development and progression of adenomatous polyps to colorectal carcinoma. The purpose of the studies conducted and reported hereafter in this thesis was to evaluate biologic changes in patients and their colorectal disease after pharmacologic inhibition of COX-2 with a selective inhibitor, celecoxib. In this thesis, I report our experience both with urine levels of the protstaglandin E2 metabolite (PGE-M) among patients with colorectal disease and changes in gene expression in rectal carcinomas after treatment with celecoxib. This research has led to the discovery of a potential biomarker of colorectal neoplasia and identified several specific genes and biologic pathways that are differentially expressed when COX-2 is pharmacologically inhibited.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-07222007-220838 |
| Date | 14 August 2007 |
| Creators | Johnson, Jeffery Chad |
| Contributors | R. Daniel Beauchamp, R. Daniel Beauchamp, R. Daniel Beauchamp, Richard Peek |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-07222007-220838/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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