In this dissertation, we explore the magnetic fields associated with action potential propagation in the spiral fiber structure of a rabbits cardiac apex. We use optical imaging, SQUID microscopy, monodomain and bidomain modeling to analyze the spiral effect on action potential propagation. We found that the spiral structure gives a distinct magnetic imprint that can be reproduced by monodomain and bidomain modeling.
The SQUID microscope has also been improved by implementing a lever mechanism and monolithic SQUID sensors for higher magnetic spatial resolution and sensitivity measurements.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-07222008-092825 |
| Date | 26 July 2008 |
| Creators | McBride, Krista Kay |
| Contributors | Michael I Miga, Alan Bradshaw, Sait A Umar, John P. Wikswo, Franz J Baudenbacher |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-07222008-092825/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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