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Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents

A mathematical approach to the concepts of copolymerization of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The structure of equations is narrowed down for the specific brand of anti-mitotic drug, colchicine. The behavior of total T-tubulin concentration in the steady state in a regeneration system is investigated and analyzed through the numerical calculations. / Ph. D.

Identiferoai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/27795
Date24 June 2005
CreatorsShojania Feizabadi, Mitra
ContributorsPhysics, Spillman, William B. Jr., Mizutani, Tetsuro, Indebetouw, Guy J., Walker, Richard A., Ritter, Alfred L.
PublisherVirginia Tech
Source SetsVirginia Tech Theses and Dissertation
Detected LanguageEnglish
TypeDissertation
Formatapplication/pdf
RightsIn Copyright, http://rightsstatements.org/vocab/InC/1.0/
RelationDissertation.pdf

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