As beta-carotene is transported via micelles across the intestinal lumen for absorption, the factors that regulate uptake into micelles could also regulate at least in part beta-carotene absorption in humans. Thus, we have studied the effect of different dietary lipids on beta-carotene uptake into mixed micelles in vitro. Using this method, the effects of fatty acids of increasing degrees of unsaturation, vitamin A, cholesterol, and vitamin E on beta-carotene uptake into micelles were studied. Uptake of beta-carotene into micelles was stimulated by cholesterol and unsaturated fatty acids (uptake correlated with degree of unsaturation). beta-Carotene solubilization into micelles was inhibited by vitamin A and vitamin E. These results suggest that the absorption of beta-carotene may be partly regulated at the level of formation of intestinal micelles by the presence of different dietary components.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/278046 |
| Date | January 1991 |
| Creators | Montano, Carlos Enrique, 1959- |
| Contributors | Canfield, Louis |
| Publisher | The University of Arizona. |
| Source Sets | University of Arizona |
| Language | en_US |
| Detected Language | English |
| Type | text, Thesis-Reproduction (electronic) |
| Rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. |
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