Part I deals with the structure determination of five organic compounds by X-ray diffraction methods: the diacetate of the sesquiterpene voleneol, which in spite of having five chiral centers, was isolated from a plant as the racemate; two 1,4-dithiin 1,1,4,4-tetroxides, one an herbicide and the other a microbiocide; bouvardin, a bicyclic hexapeptide with anti-tumor activity; and a tripeptide that is an intermediate in a synthesis of the anti-tumor agent deoxybouvardin and which contains a novel hydrogen bond. Part II details efforts to synthesize deoxybouvardin. Compounds synthesized include the corresponding monocyclic hexapeptide (which shows no anti-tumor activity) and various precursors to the 14-membered ring of deoxybouvardin.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/282227 |
| Date | January 1980 |
| Creators | Kriek, George Robert |
| Publisher | The University of Arizona. |
| Source Sets | University of Arizona |
| Language | en_US |
| Detected Language | English |
| Type | text, Dissertation-Reproduction (electronic) |
| Rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. |
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